Allergy Sufferer? This may help

 Vac your mattress. It's not a fun chore, but it is necessary.

The easiest way to remove dust is to use the upholstery tool on your vac. It's a good idea to do this every couple of months or more often if you suffer from allergies. 

Press down on the tool or tap it on the fabric to draw out dust beneath the surface. Then, use the crevice tool to get into the quilting. 

Some newer vacs come with tools that vibrate against mattress and upholstery fabrics to better draw out dust.